QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bergeron, R. J. Articles by Elliott, G. T. Search for Related Content PubMed PubMed Citation Articles by Bergeron, R. J. Articles by Elliott, G. T.

Influence of Iron on In Vivo Proliferation and Lethality of L1210 Cells

Department of Medicinal Chemistry, Department of Medicine, University of Florida, Gainesville, FL 32610

The ability of iron to stimulate the growth of L1210 cells both in DBA-2 mice and in cell culture is evaluated. Although in vitro stimulation is absent, in vivo studies clearly indicate higher numbers of tumor cells in the presence of supplemental iron. When mice were given iron i.p., at levels comparable to clinical doses for humans (24 mg/kg body weight), the tumor load recovered from their peritoneum was substantially greater than from controls without iron supplements. Furthermore, at higher levels of supplemental iron (250 mg Fe/kg body weight), the pretreated animals inoculated with L1210 cells died in 9.7 d whereas controls died in 12.2 d (i.e., 25% faster). As expected, the lower iron dose (24 mg/kg) also resulted in shorter life spans, although the effects were less striking. It is the belief of these authors that these data support the opinion that "anemia of chronic disease" associated with leukemia and possibly other malignancies may represent a host defense mechanism as has been postulated by others (1, 8).

KEY WORDS: • iron • neoplasm

Manuscript received 1 October 1984.

This article has been cited by other articles:

				A. M. Siesky, L. M. Kamendulis, and J. E. Klaunig Hepatic Effects of 2-Butoxyethanol in Rodents Toxicol. Sci., December 1, 2002; 70(2): 252 - 260. [Abstract] [Full Text] [PDF]