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Effects of Dietary Carbohydrate on Mitochondrial Composition and Function in Two Strains of Rats^1,2,

University of Georgia, Department of Foods and Nutrition, Athens, GA 30602

BHE and Wistar male, weanling rats were fed either a 65% sucrose or a 65% cornstarch diet. They were killed at 50 d of age; livers were excised and used for the determination of the fatty acids of mitochondrial phospholipid or used to determine the effect of such diets on the dependence on temperature of succinate-supported respiration. Neither diet nor strain affected either the total quantity of phospholipids or the quantities of the individual phospholipids. However, analysis of variance revealed strain and diet differences in the fatty acyl moieties of the phospholipids: sucrose-fed rats had more stearic (18:0) and less linoleic acid (18:2) than did starch-fed rats; BHE rats had more arachidonic acid (20:4) than did Wistar rats. There were no significant differences in either transition temperature or in the lower or upper activation energies determined from the biphasic Arrhenius plot. Although fatty acid compositional differences were observed, these differences had little effect on the membrane-associated, succinate-supported respiration.

KEY WORDS: • BHE rat • carbohydrate • mitochondria • phospholipids • cholesterol • Arrhenius plot

¹ A preliminary report on these data was presented in poster form at the 1982 Federation of American Societies for Experimental Biology meetings in New Orleans, LA.

² Research supported by Georgia Agricultural Experiment Station Project H635, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases of the National Institutes of Health Station Project H635, Grant AM21667 and U.S. Department of Agriculture Cooperative Agreement No. 58-32U4-2-361.

³ To whom correspondence should be addressed.

Manuscript received 10 August 1984.

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