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The Effect of Dietary Protein on the Metabolism of Vitamin B-6 in Humans^1,2,3,

Department of Foods and Nutrition, Oregon State University, Corvallis, OR 97331

Eight men, aged 21–31 yr, were fed semipurified diets containing 0.5 (low), 1.0 (medium) and 2.0 (high) g protein/kg body weight; vitamin B-6 intake was kept constant at 1.6 mg/d. Each level of protein was fed for 15 d. Urinary vitamin B-6 (UB-6), urinary 4-pyridoxic acid (4-PA), plasma total vitamin B-6 (PB-6) and plasma pyridoxal 5'-phosphate (PLP) were determined every third day. Means are reported for all subjects of values determined during the second half of each period. Concentration of urinary and plasma vitamin B-6 compounds were negatively correlated with protein intake: the correlation coefficient of nitrogen intake with 4-PA was -0.69 (P < 0.01); with PLP, -0.45 (P < 0.05); and with PB-6, -0.48 (P < 0.05). The decrease in UB-6 was not statistically significant. These results indicate that with increased intake of dietary protein, vitamin B-6 is retained in the body for increased catabolism of amino acids. When evaluating vitamin B-6 requirements or status in humans, protein intake must be considered.

KEY WORDS: • vitamin B-6 • dietary protein • pyridoxal 5'-phosphate • 4-pyridoxic acid • human

¹ Oregon Agricultural Experiment Station Technical Paper No. 7442.

² Funded by U.S. Department of Agriculture Cooperative State Research Service (CSRS) Grant 616-15-177.

³ A preliminary report was presented at the 1978 meeting of the Federation of American Societies for Experimental Biology in Atlantic City, NJ: Miller, L. T. & Leklem, J. E. (1978) Effect of dietary protein on metabolism of vitamin B-6. Fed. Proc. 37, 449 (abs. 1259).

⁴ Present address: Loma Linda University, School of Medicine, Department of Biochemistry, Loma Linda, CA 92350.

Manuscript received 22 February 1985. Revision accepted 29 August 1985.

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