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Influence of Magnesium Deficiency on Liver Collagen after Carbon Tetrachloride or Ethanol Administration to Rats

Institut National de la Recherche Agronomique, Theix 63122 Ceyrat, France

The effects of magnesium deficiency on liver collagen after the administration of a hepatotoxic substance were investigated. Rats, fed a control or magnesium-deficient diet (0.040 g/kg), received six CCl₄ or mineral oil injections administered at 2-d intervals starting from the first day of diet treatment. They were killed 3 or 12 d after the last injection. Between postinjection d 3 and 12, no change of magnesium concentration in liver was observed in the deficient rats. Three days after the end of treatment liver calcium in the magnesium-deficient CCl₄-treated rats was higher than in any other group. Liver collagen of untreated control rats and untreated magnesium-deficient rats was not significantly different. In control and magnesium-deficient animals receiving CCl₄ treatment, the liver collagen levels were significantly higher than in untreated rats. The magnesium-deficient rats receiving CCl₄ have higher liver collagen than the controls receiving CCl₄. In a second experiment the effect of suboptimum intake of magnesium (0.120 g/kg) combined with the ingestion of ethanol was studied in rats given a solution of ethanol in water for 55 d as their only source of fluid. Mortality occurred in the magnesium-deficient rats receiving ethanol, and body weights of these rats were lower than those of animals in the other three groups. The collagen concentration in liver was higher in magnesium-deficient rats consuming ethanol than in any other groups. The synergistic action between magnesium deficiency and ethanol therefore appears to be analogous to that observed with CCl₄.

KEY WORDS: • magnesium deficiency • collagen • liver • ethanol

Manuscript received 8 November 1984. Revision accepted 5 August 1985.

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