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Effect of Ambient Temperature on the Toxicity of Palmitoyl Glycerol in Weanling Mice^1,2,

Department of Biochemistry, Box 7622, North Carolina State University, Raleigh, NC 27695-7622

The toxicity of dietary rac-1(3)-palmitoyl glycerol in weanling mice was greatly exacerbated when the animals were kept at low ambient temperatures. Death occurred at temperatures below 25°C but did not occur when the temperature was between 27 and 35°C. As observed previously, supplementing the diet with 4% safflower oil afforded some protection against the toxicity of palmitoyl glycerol. In contrast, the interstitial pneumonitis, usually observed when palmitoyl glycerol is fed, was found in the lungs of animals at all temperatures. These findings show that the lung lesion is not the immediate cause of death.

KEY WORDS: • palmitoyl glycerol • temperature effect • safflower oil • toxicity • pneumonitis

¹ Contribution from the Department of Biochemistry, School of Agriculture and Life Sciences and School of Physical and Mathematical Sciences. Paper No. 9761 of the Journal Series of the North Carolina Agricultural Research Service, Raleigh, North Carolina 27695-7601.

² This work was supported in part by Grant DAAG29-78-G-0006 from the United States Army Research Office.

³ Present address: Department of Biochemistry and Nutrition, University of North Carolina School of Medicine, Chapel Hill, NC 27514.

Manuscript received 4 March 1985. Revision accepted 5 August 1985.