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Effect of Molybdenum-Deficient and Low Iron Diets on Xanthine Oxidase Activity and Iron Status in Rats^1,2,

Department of Nutritional Sciences, University of California, Berkeley, CA 94720

We tested the hypothesis proposed by Topham, Woodruff and Walker that intestinal xanthine oxidase is important for iron absorption. We made weanling rats xanthine oxidase-deficient and measured their growth and iron status. There were no significant differences between control and xanthine oxidase-depleted rats in growth or iron absorption or a variety of measures of iron metabolism, except that xanthine oxidase-depleted rats accumulated nonheme iron in the liver. Iron deficiency caused a loss in intestinal xanthine oxidase activity, but also caused an increase in hepatic xanthine oxidase activity. This result may be important for understanding changes in purine and protein metabolism during iron deficiency.

KEY WORDS: • xanthine oxidase • molybdenum deficiency • iron status • trace metals

¹ A preliminary report of this research was presented in part at the 66th Annual Meeting of the Federation of American Societies for Experimental Biology, New Orleans, LA, April 1982, Kelley, M. K. & Amy, N. K., Fed. Proc. 41, 286 (abs. 102).

² This study was supported in part by the California Agricultural Experimental Station.

³ To whom correspondence should be sent.

Manuscript received 20 February 1984.

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