Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 114 No. 9 September 1984, pp. 1602-1608
Copyright
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nakano, K.
Right arrow Articles by Suzuki, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nakano, K.
Right arrow Articles by Suzuki, S.

Stress-Induced Change in Tissue Levels of Ascorbic Acid and Histamine in Rats1

Kiwao Nakano and Seiji Suzuki

Department of Nutritional Regulation, Research Institute for Biochemical Regulation, Nagoya University, Chikusa, Nagoya 464, Japan

Effects of acute immobilization stress on the metabolism of ascorbic acid and histamine were studied in rats by determining changes in the tissue levels of these substances. Stress provoked a significant rise in the histamine levels of blood, stomach, kidney, lung and skin. The serum ascorbic acid level increased rapidly, whereas the amount of the vitamin in the lung and skin was reduced by stress. The hepatic ascorbic acid levels were modulated biphasically; there was a decrease within 15 minutes after the onset of the stress regimen, followed by an increase occurring during the next 15 minutes. There was a gradual decrease in the amount of ascorbic acid in the adrenal glands with a marked transient accumulation of corticosterone in the tissues. Administration of histamine caused an increase in the serum level of ascorbic acid, while it led to a transitory decrease in the hepatic level of the vitamin. These results suggest that the metabolism of ascorbic acid is modulated in rats suffering from stress. These changes in ascorbic acid metabolism seem to be closely associated with the stress-induced alteration of histamine metabolism.

KEY WORDS: • stress • ascorbic acid • histamine

1 This work was supported by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, and a grant from the Ishida Foundation.

Manuscript received 18 January 1984.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]