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Nondigestibility of a New Sweetener, "Neosugar," in the Rat¹

Department of Nutrition, School of Health Sciences, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo, Tokyo 113, Japan

The digestion of Neosugar, a mixture of 1^F-(1-ß-fructofuranosyl)_n-1 sucrose [n = 2, 1-kestose (GF₂); n = 3, nystose (GF₃); n = 4, 1^F-ß-fructofuranosyl nystose (GF₄)] was investigated in vitro and in vivo by using the rat. The results obtained were as follows. GF₂ and GF₃ were not hydrolyzed by a pancreatic homogenate. The GF₂- and GF₃-hydrolyzing activities of the enzymes in the intestinal mucosa homogenate were negligible compared with the activities of maltase and sucrase. GF₂ and GF₃ added to the incubation mixture did not affect the activities of sucrase and maltase in the intestinal mucosa. Long-term ingestion of Neosugar did not cause induction or suppression of GF₂- and GF₃-hydrolyzing enzymes in the small intestine. [U-¹⁴C]Neosugar injected intravenously was rapidly excreted in the urine without having undergone any degradation. These results indicate that Neosugar, which consists of GF₂, GF₃ and GF₄, is scarcely hydrolyzed by the digestive enzymes of the gastrointestinal tract and internal organs, and that suggests to us that Neosugar is not utilized as an energy source in the body.

KEY WORDS: • Neosugar • sweetener • new sweetener

¹ The results in this paper were orally presented at the 37th annual meeting of the Japanese Society of Nutrition and Food Science in Osaka, Japan, May 8–10, 1983. Nondigestibility of fructooligosaccharide, Neosugar, in rat. Proceedings, p. 168.

Manuscript received 23 November 1983.

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