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Utilization of Dietary Tryptophan in Iron-Deficient Rats

D. C. Sharma and M. M. Simlot*

Departments of Biochemistry, R. N. T. Medical College, Udaipur * Rajasthan College of Agriculture, Udaipur, India 313001

Excretion of urinary tryptophan in iron-deficient rats increased threefold while the excretion of N-methyl nicotinamide, a catabolic product of tryptophan, decreased by one-half compared to control rats. The activity of hepatic tryptophan oxygenase, the first enzyme of tryptophan metabolism, was not affected by iron deficiency. It is concluded that tryptophan supplementation in severe iron deficiency would not be beneficial.

KEY WORDS: • iron deficiency • tryptophan metabolism • tryptophan oxygenase

Manuscript received 1 February 1984.




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