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Department of Psychology, University of Massachusetts, Amherst, MA 01003 Department of Psychology, Rhode Island College, Providence, RI 02094 and Monell Chemical Senses Center, Philadelphia, PA 19104
The effects of early gestational undernutrition and subsequent re-feeding patterns on offspring food intake, body weight and adiposity were examined. Pregnant rats were food restricted to 50% of their preconception intake levels during the first 2 weeks of pregnancy and were then either returned to ad libitum feeding or pair-fed to nonrestricted control rats. Male and female offspring of previously deprived, ad libitum refed mothers gained significantly more weight when fed a standard low fat, high carbohydrate diet than did control offspring. When the maintenance diet was changed at 140 days of age to a high fat diet, both groups of previously deprived male offspring gained weight at greater than control rates. In contrast, the three groups of female rats gained weight at comparable rates after the diet change. Adipocyte hypertrophy and elevated carcass lipid content were seen in high fat—fed male but not female offspring of previously deprived mothers. Adipose tissue lipoprotein lipase activity was unaffected by these manipulations.
KEY WORDS: • undernutrition • gestation • adipocyte • obesity
1 This research was supported by National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases of the National Institutes of Health Grant No. AM-31634.
2 Present address: Box C-233, University of Colorado, Denver, CO 80262. To whom reprint requests should be addressed.
Manuscript received 16 January 1984.
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