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Reduction of Plasma Lecithin—Cholesterol Acyltransferase Activity by Acute Magnesium Deficiency in the Rat

Laboratoire des Maladies Métaboliques, Institut National de la Recherche Agronomique, Theix, 63122 Ceyrat, France ^* Laboratoire de Biochimie, Hôpital Saint-Antoine, 75571 Paris, France

Weanling Wistar rats were pair-fed for 8 days control and magnesium-deficient diets. Acute magnesium deficiency increased plasma triglycerides and free cholesterol levels and decreased esterified cholesterol levels. The plasma activity of lecithin—cholesterol acyltransferase was markedly diminished in fasting magnesium-deficient rats (54% reduction) and plasma high density lipoprotein (HDL) free cholesterol was significantly increased in the HDL fraction. The results of this study showing that dietary magnesium affects the activity of the enzyme involved in the esterification of free cholesterol to cholesterol ester provide a possible basis for the reduced plasma cholesterol esterification and hyperlipidemia associated with acute magnesium deficiency.

KEY WORDS: • magnesium deficiency • lecithin—cholesterol acyltransferase

¹ Present address: Laboratoire de Pharmacologie Médicale et Hydrologie, U195 INSERM, Faculté de Médicine, 63000 Clermont-Ferrand, France.

² To whom reprint requests should be sent.

Manuscript received 24 January 1984.

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