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Journal of Nutrition Vol. 114 No. 6 June 1984, pp. 1130-1136
Copyright © 1984 by American Society for Nutrition
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Effects of Dietary Vitamin E on Serum and Pulmonary Fatty Acids and Prostaglandins in Rats Fed Excess Linoleic Acid1

Elisabeth Schafer and Lotte Arnrich2

Department of Food and Nutrition, Iowa State University, Ames, IA 50011

The interrelationships of dietary vitamin E and essential fatty acids and their effects on serum and pulmonary prostaglandin (PG) synthesis and fatty acid precursors were examined. In a preexperimental period, male weanling rats were depleted of essential fatty acids (EFA) by feeding on a hydrogenated coconut oil diet. At the end of 45 days, average serum triene:tetraene ratio for the EFA-deficient rats was 0.76. After a refeeding period with a 20% safflower oil diet and 0, 1 or 50 mg of dl-{alpha}-tocopheryl acetate daily, serum and pulmonary fatty acid profiles and PG synthesis were determined. A trend to growth depression on the high vitamin E diet was observed. Vitamin E supplementation seemed to have no significant effect on fatty acid composition or synthesis of PGE1, PGE2, PGF2{alpha} or PGI2 in lung. This may be due to the small lipid content and presumed inability of lung to accumulate excess vitamin E. Lung may, therefore, be resistant to such dietary manipulations. Serum PG synthesis was not affected by vitamin E dose, although the C20:4{omega}6/C18:2{omega}6 ratio in serum was significantly lowered on the high vitamin E diet.

KEY WORDS: • vitamin E • prostaglandins • fatty acids

1 This work was supported by North Central Regional Project NC-95, Nutritional Impacts of Fat-Altered Diets. Journal Paper No. J-11115, the Iowa Agriculture and Home Economics Experiment Station, Ames, IA. Project No. 2154.

2 Current address: 777 Cragmont Avenue, Berkeley, CA 94708.

Manuscript received 30 January 1984.




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