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Portal Absorption of Small Peptides in Rats under Unrestrained Conditions

Hiroshi Hara^*,,, Ryuhei Funabiki^*, Mitsuo Iwata and Ken-Ichi Yamazaki

^* Faculty of Agriculture, Tokyo Noko University, 3-5-8 Saiwaicho, Fuchu-shi, Tokyo 183, Japan Technical R&D Division, Terumo Corporation, 2-44-1 Hatagaya, Shibuya-ku, Tokyo 151, Japan

The intestinal absorption of small peptides was investigated in rats under unrestrained conditions. The peptide utilized in the experiment was hydrolysate of egg white protein with an average molecular weight of about 350 and containing less than 10% of free amino acids. We compared the intestinal absorption of these small peptides with that of an amino acid mixture with the same small peptide amino acid composition by determining the concentration of individual amino acids in portal blood after a single administration of a nitrogen source. The absorptive intensity of each amino acid was calculated from its rate of elevation in the portal blood; it was higher in the small peptides. The proportion of the amount of each amino acid absorbed in portal blood from small peptides was much more like the composition of the administered amino acids than like that from the amino acid mixture. Among the amino acids administered in the mixture, some amino acids such as L-tyrosine, L-threonine, L-serine and L-hisitidine increased more slowly in the blood than others. These results suggested that the small peptide formula was utilized more effectively than the amino acid mixture and had higher nutritive value.

KEY WORDS: • small peptide • intestinal absorption • portal cannulation • amino acid mixture

Manuscript received 11 October 1983.

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				E. R. Gilbert, E. A. Wong, and K. E. Webb Jr. BOARD-INVITED REVIEW: Peptide absorption and utilization: Implications for animal nutrition and health J Anim Sci, September 1, 2008; 86(9): 2135 - 2155. [Abstract] [Full Text] [PDF]