Journal of Nutrition

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Journal of Nutrition Vol. 114 No. 6 June 1984, pp. 1070-1075
Copyright © 1984 by American Society for Nutrition
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Protection against Sucrose-Induced Retinal Capillary Damage in the Wistar Rat1

Janet M. Thornber and Curtis D. Eckhert

School of Public Health, University of California, Los Angeles, CA 90024

The procedure of rearing rats on high sucrose diets has been used in some laboratories as a drug-free model to induce retinal vascular-bed damage resembling diabetic retinopathy. Examination of dietary salt mixes used in laboratories reporting success with this model revealed that two essential elements, chromium and selenium, were not included. The present study evaluated the effect of supplementing a high sucrose diet, reported to induce retinopathy, with chromium and selenium. Selenium supplementation significantly reduced the number of acellular collapsed capillary strands within arterial-venous capillary networks. The addition of chromium to the high sucrose diet resulted in lower fasting blood glucose and a smaller rise in its level following an oral dose. Little or no retinal vascular damage was apparent in rats fed the high sucrose diet supplemented with chromium, selenium and additional corn oil. Of the two elements, only supplementation with Se protected the retinal capillaries from damage.

KEY WORDS: • retinal disease • retinopathy • microangiopathy • diabetic retinopathy • choroid • capillary • sucrose • chromium • selenium • trace elements

1 This project was supported in part by Biomedical Research Support Grant SO 7 RR 5442 awarded by the Division of Research Resources, National Institutes of Health, and Grant No. 1 RO3 EYO4230-01A1 of the National Eye Institute, National Institutes of Health.

Manuscript received 22 August 1983.




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