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The Effect of Vitamin B-6 Deficiency on Host Susceptibility to Moloney Sarcoma Virus-Induced Tumor Growth in Mice^1,2,

Department of Foods and Nutrition ^* College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331

The effect of vitamin B-6 deficiency on in vivo host susceptibility to primary Moloney sarcoma virus (MSV)-induced tumor growth and to secondary challenge with MSB sarcoma cells was examined in mice. Female C57BL/6 mice, 6 weeks of age, were fed 20% casein diets with pyridoxine (PN) added at 1, 0.5, 0.1 or 0 mg/kg diet for 21 weeks. After 4 weeks of dietary treatment the mice were challenged with MSV. Vitamin B-6 deficiency resulted in an enhancement of tumor susceptibility as well as an increase in tumor size and regression time. The animals resistant to both MSV and MSV-transformed tumor cells (MSB) challenge showed splenic tumor development at necropsy 51 days after MSB challenge. Total incidence of MSV/MSB/splenic tumors was 2/11, 2/11, 4/10 and 8/11 in animals fed PN 1, 0.5, 0.1 and 0 diets, respectively. Since MSV-induced tumors regressed spontaneously in immunocompetent hosts, the increased susceptibility to MSV oncogenesis in vitamin B-6-deficient animals suggests that reactivity of T cells and/or other effector cells is impaired in vitamin B-6-deficient animals suggests that reactivity of T cells and/or other effector cells is impaired in vitamin B-6 adequacy.

KEY WORDS: • vitamin B-6 • pyridoxine • Moloney sarcoma virus • MSB

¹ Technical Paper No. 6977 from Oregon Agricultural Experiment Station. Supported by OAES and LAR, Oregon State University.

² Preliminary report presented at the 67th annual meeting of the Federation of American Societies for Experimental Biology, Chicago, IL. Ha, C., Miller, L. T. & Kerkvliet, N. I. (1983) Influence of pyridoxine deficiency on antitumor cytotoxic immune reactivity in mice. Fed. Proc. 42, 1326.

³ Address reprint requests to: Dr. L. T. Miller, Department of Foods and Nutrition, Oregon State University, Corvallis, OR 97331.

Manuscript received 18 October 1983.