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Journal of Nutrition Vol. 114 No. 5 May 1984, pp. 920-928
Copyright © 1984 by American Society for Nutrition
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Decrease in Bone Density in Young Male Guinea Pigs Fed High Levels of Ascorbic Acid1,2,

Diane L. Bray and George M. Briggs

Department of Nutritional Sciences, University of California, Berkeley, Berkeley, CA 94720

These experiments were conducted to investigate the effects of high oral intakes of ascorbic acid on bone metabolism in young guinea pigs and to inquire into the mechanism mediating these effects. Male guinea pigs 14 days old fed 8.7% of ascorbic acid for 6 weeks had decreased bone density and decreased urinary hydroxyproline compared to control animals fed 0.2% of ascorbic acid. To assess whether these changes were due to the acidity of the diet or to vitamin activity, salts of ascorbic acid, salts of erythorbic acid and free erythorbic acid were fed. There were no significant bone changes in any of these groups. The results strongly indicate that the acidity of ascorbic acid plays a part in the decrease in bone density but do not rule out that some other metabolic property specific to ascorbic acid may also be implicated.

KEY WORDS: • ascorbic acid • hydroxyproline • bone density

1 Supported in part by National Institutes of Health Predoctoral Traineeship No. GMS-01188.

2 From a thesis submitted in June 1977 by Diane L. Bray in partial fulfillment of the requirements for the degree of Doctor of Philosophy, University of California, Berkeley. Abstract: Bray, D. L. & Reyes, P. S. (1976) Decreased urinary hydroxyproline in the guinea pig on high intakes of ascorbic acid. Fed. Proc. 35, 661.

Manuscript received 10 October 1983.




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