Journal of Nutrition

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Salminen, E.
Right arrow Articles by Koivistoinen, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Salminen, E.
Right arrow Articles by Koivistoinen, P.

The Effects of Xylitol on Gastric Emptying and Secretion of Gastric Inhibitory Polypeptide in the Rat

E. Salminen*, S. Salminen{dagger}, L. Porkka{ddagger} and P. Koivistoinen{dagger}

* The Radiotherapy Clinic {ddagger} Department of Nuclear Medicine, Central University Hospital, 00290 Helsinki, Finland the{dagger} Department of Food Chemistry, University of Helsinki, 00710 Helsinki, Finland

The effects of xylitol on the rate of gastric emptying and plasma gastric inhibitory polypeptide secretion in the rat were studied to relate xylitol adaptation to these phenomena. Male Sprague-Dawley rats, weighing about 250–270 g, were either gradually adapted to 20% xylitol diets or given a basal diet. The animals were, after a 24-hour fast, given a 1.2 g/kg body weight dose of xylitol or glucose either alone or with a 99mTc-tin colloid marker to study gastric emptying by using a gamma camera. Blood was taken from the tail vein, and plasma was analyzed for immunoreactive gastric inhibitory polypeptide by using a double-antibody radioimmunoassay. Xylitol adaptation did not appear to have any effect on the secretion of gastric inhibitory polypeptide. However, adaptation of rats to 20% dietary xylitol appeared to change the rate of gastric emptying by decreasing it. Therefore, it was concluded that gastric emptying plays a role in the adaptation to high xylitol doses while gastric inhibitory polypeptide appears not to be involved.

KEY WORDS: • xylitol • glucose • gastric emptying • gastric inhibitory polypeptide • xylitol adaptation

Manuscript received 16 March 1984.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 1984 by American Society for Nutrition