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Antirachitic Activity of 1{alpha}-Hydroxyergocalciferol and 1{alpha}-Hydroxycholecalciferol in Rats

G. Sjöden, J. U. Lindgren and H. F. DeLuca*

Department of Orthopaedic Surgery, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge, Sweden * Department of Biochemistry, University of Wisconsin, Madison, WI 53706

Weanling vitamin D-deficient rats fed a high calcium, low phosphate diet were injected daily with 1{alpha}-hydroxyergocalciferol or 1{alpha}-hydroxycholecalciferol at doses of 2.5, 25 or 250 ng. Intestinal calcium and phosphate transport, serum phosphorus level, epiphyseal plate calcification, and percent femur ash increased as a function of the dose. Both compounds were equally effective in eliciting these responses demonstrating their equivalency as antirachitic compounds.

KEY WORDS: • calcium transport • intestine • phosphate transport • rickets • vitamin D

Manuscript received 9 July 1984.




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