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Interaction between Ethanol and Low Dietary Zinc during Gestation and Lactation in the Rat1,2,

Lee-Chuan C. Yeh and Florian L. Cerklewski3

College of Home Economics, Department of Foods and Nutrition, Oregon State University, Corvallis, OR 97331

Pregnant rats were fed individual liquid diets throughout gestation and lactation. The diets contained either 2 or 10 µg zinc/ml diet with or without 30% of the kilocalories supplied from ethanol. The low zinc diet produced a moderate zinc deficiency in dams evidenced by decreases in tissue zinc content, serum alkaline phosphatase activity and urinary zinc concentration. Despite the presence of high zinc content in the diet, ethanol antagonized the maternal zinc status to a level typical of that produced by the low zinc diet. The lowest zinc status, however, was found when low dietary zinc and ethanol were combined. The maternal interaction between ethanol and zinc also depressed offspring serum zinc and alkaline phosphatase activity in a similar manner. Ethanol, however, did not affect tissue content of calcium, magnesium or phosphorus, which indicates that ethanol is a specific antagonist of zinc utilization during gestation and lactation.

KEY WORDS: • ethanol • zinc

1 Taken in part from a thesis submitted by Lee-Chuan C. Yeh to Oregon State University in partial fulfillment of the requirements for a doctorate degree.

2 Oregon Agricultural Experiment Station Technical Paper no. 7047.

3 To whom reprint requests should be sent.

Manuscript received 17 April 1984.




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