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Changes in the Levels of Marker Expression by Mononuclear Phagocytes in Zinc-Deficient Mice¹

Julia J. Wirth^*, P. J. Fraker and F. Kierszenbaum^*

^* Department of Microbiology and Public Health Department of Biochemistry, Michigan State University, East Lansing, MI 48824

To define the effects of dietary zinc deficiency on mononuclear phagocytes young adult A/J mice were fed zinc-deficient, zinc-adequate, or restricted amounts of a zinc-adequate diet for 28 days. The deficiency did not affect the total number or the percentage of nonspecific esterase (NSE)-positive cell populations in the blood or peritoneal cavity of the mice; however, the total numbers of leukocytes and NSE-positive cells in the spleen were reduced in the deficient and restricted mice to about 50% of the zinc-adequate group. In the peripheral blood of deficient mice, the percentages of adherent cells expressing Fc (FcR) and complement (CR) receptors were five and two times greater, respectively, than zinc-adequate controls. The FcR-bearing cells of the spleens of zinc-deficient mice were also increased twofold over controls. Adherent cells from the peripheral blood and spleen of zinc-deficient mice were able to phagocytize a slightly greater number of latex particles than cells from the zinc-adequate or restricted mice. The presence of zinc in fetal bovine serum did not enhance the ability of mononuclear phagocytes from deficient mice to engulf latex in vitro.

KEY WORDS: • phagocytes • monocytes • zinc deficiency • phagocytosis • complement receptors

¹ This research was supported in part by U.S. Public Health Service Research Grants Al 14848 and Al 17041, National Institutes of Health Training Grants Al-07203 and HD-10586.

Manuscript received 17 February 1984.