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Dietary Trilinoelaidate: Effects on Organ Fatty Acid Composition, Prostanoid Biosynthesis and Platelet Function in Rats¹

Department of Food Science, Cornell University, Ithaca, NY 14853

Incremental levels of trilinoelaidate (tt18:2) were fed to rats for 11 weeks and changes in lung and epididymal lipid fatty acid composition were determined, and concentrations of prostanoids in serum, lung and stomach fundus were measured. Platelet aggregation to various agonists was tested. In the lung there was a concomitant increase of linoelaidate corresponding to incremental dietary levels in all lipid classes (phosphatidylcholine, phosphatidylethanolamine, phosphatidyl-serine-phosphatidylinositol and neutral lipids). Arachidonic acid in lung phosphatidylcholine was markedly decreased. Epididymis accumulated linoelaidate in only the neutral lipid fraction; no tt18:2 was found in any of the phospholipid classes. Serum prostanoid levels (thromboxane B₂ and prostaglandins PGF₂ and PGE) were significantly decreased in rats fed high levels of tt18:2, but were not altered at lower levels of consumption; the concentrations of 6-keto-PGF₁ were not significantly altered at any level of tt18:2. Platelet responsiveness to various agonists was not significantly altered by incremental dietary trilinoelaidate, i.e., ADP, thrombin, collagen and calcium elicited similar aggregation responses. In conclusion, dietary trilinoelaidate at low levels of consumption, while being incorporated into various lipid classes, did not alter serum and tissue prostanoid levels or markedly affect platelet aggregation.

KEY WORDS: • linoelaidate • prostaglandins • fatty acids • trans fatty acids • platelets

¹ Supported by U.S. Department of Agriculture Science and Education Administration Grant No. 5901-0410-9-0286-0.

² Present address: Department of Clinical Nutrition, University of Kentucky, Lexington, KY 40506.

Manuscript received 21 March 1983.

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