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Control of Physiological Response in the Rat by Dietary Nutrient Concentration

L. Preston Mercer, Jon M. Gustafson, Paul T. Higbee, Charles E. Geno, Michael R. Schweisthal and Thomas B. Cole

Departments of Biochemistry and Anatomy, School of Medicine, Oral Roberts University, Tulsa, OK 74171

In three separate experiments, growing, male Sprague-Dawley rats were fed diets which contained: 1) graded levels of fiber 0–70%, 2) graded levels of pyridoxine 1–10 mg/kg diet, and 3) graded levels of casein 0–30%. The following physiological responses were measured in each respective experiment: 1) food intake, weight gain, serum triglycerides, 2) food intake, weight gain, SGPT levels, and 3) weight specific food intake, weight gain, relative testes weight. Diets were fed as a single source, and in each case, physiological response could be predicted as a function of dietary nutrient concentration. When self-selection is prevented, rats establish new steady-state response profiles, which are sigmoidal in shape and dependent on the interaction of the rats' genetic potential with the environmental configuration.


KEY WORDS: • food intake • growth • fiber • pyridoxine • casein

Manuscript received 17 June 1983.





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