QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lawson, L. D. Articles by Holman, R. T. Search for Related Content PubMed PubMed Citation Articles by Lawson, L. D. Articles by Holman, R. T.

Suppression of Arachidonic Acid in Lipids of Rat Tissues by Dietary Mixed Isomeric cis and trans Octadecenoates¹

The Hormel Institute, University of Minnesota, Austin, MN 55912

The influence of dietary isomeric cis and trans octadecenoic fatty acids (ICTO) on the metabolism of polyunsaturated fatty acids in rat tissues was studied by feeding a defined diet rich in partially hydrogenated soybean oil. Experimental and control animals received equal and more than adequate amounts of linoleic and linolenic acids. The total phospholipid (PL) fatty acids of liver, heart, testis, brain and sciatic nerve, and the fatty acids of liver triacylglyceride, cholesteryl ester and individual PL classes were analyzed by capillary gas chromatography. The content of arachidonic acid in the total fatty acids of liver lipids of ICTO-fed rats was found to be lower than those from control rats by the following amounts (in percent): total PL, 35; phosphatidylcholine, 50; phosphatidylinositol, 35; phosphatidylserine 26; phosphatidylethanolamine, 12; cholesteryl ester, 55; and tryglyceride 75. PL 18:26 and 20:36 levels were elevated, suggesting inhibition of the desaturase-elongase enzymes involved in synthesis of arachidonic acid. Synthesis of 20:53 and 20:39 was accentuated by the ICTO diet, suggesting an 6 series-specific inhibition. A nearly perfect negative correlation between cis 12–18:1 and arachidonic acid was found in liver PL.

KEY WORDS: • trans fatty acids • polyunsaturated fatty acids • arachidonic acid • partially hydrogenated vegetable oil • isomeric octadecenoic acids

¹ Supported in part by National Institutes of Health Grant No. HL 21513; Program Project Grant HL 06214; Program Profects Branch, Extramural Programs, National Heart, Lung and Blood Institute; Center Grant NS 14304, National Institute of Neurological and Communicative Disorder and Stroks; and by the Hormel Foundstion.

² Present address: Department of Medicine, Digestive Diseases and Nutrition, University of North Carolina, Chapel Hill, NC 27514.

³ To whom reprint requests should be sent.

Manuscript received 27 January 1983.

This article has been cited by other articles:

				E. Villamor, I. N Koulinska, J. Furtado, A. Baylin, S. Aboud, K. Manji, H. Campos, and W. W Fawzi Long-chain n 6 polyunsaturated fatty acids in breast milk decrease the risk of HIV transmission through breastfeeding Am. J. Clinical Nutrition, September 1, 2007; 86(3): 682 - 689. [Abstract] [Full Text] [PDF]

				E. Szabo, G. Boehm, C. Beermann, M. Weyermann, H. Brenner, D. Rothenbacher, and T. Decsi trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk: results of a large birth cohort study Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1320 - 1326. [Abstract] [Full Text] [PDF]