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Effect of Citrate, Glutathione and Picolinate on Zinc Transport by Brush Border Membrane Vesicles from Rat Intestine^1,2,

Department of Nutrition, Rutgers University, New Brunswick, NJ 08903 and Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611

Brush border membrane vesicles were used to evaluate the influence of a variety of potential zinc-binding ligands on zinc transport in the rat. Citrate, glutathione (reduced) and picolinate were added to the extravesicular incubation medium at 0.38 mM. Transport was evaluated for up to 60 minutes at an extravesicular zinc concentration of 0.2 mM. Citrate depressed zinc transport at each time point checked. Picolinate depressed transport after 5 minutes of incubation. Glutathione slightly enhanced transport after 60 minutes of incubation. Neither citrate, glutathione nor picolinate had an influence on D-glucose transport. These results suggest that the compounds evaluated do not enhance zinc transport across the brush border surface of the small intestine of the rat.

KEY WORDS: • nutrient absorption • intestinal absorption • zinc absorption

¹ Supported in part by National Institutes of Health Grants AM 31127 from the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases and ES03103 from the National Institute of Environmental Health Sciences and by the New Jersey Agricultural Experiment Station.

² Presented in part at the American Institute of Nutrition Meeting, New Orleans, LA, April 1982. Fed. Proc. 41, 779 (abs.).

³ Present address: Travenol Laboratories, Inc., Nutrition and Flow Control Division, Deerfield, IL 60015.

⁴ To whom all inquiries and reprint requests should be addressed.

Manuscript received 11 February 1983.