QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wolf, R. N. Articles by Grundy, S. M. Search for Related Content PubMed PubMed Citation Articles by Wolf, R. N. Articles by Grundy, S. M.

Influence of Exchanging Carbohydrate for Saturated Fatty Acids on Plasma Lipids and Lipoproteins in Men

Department of Medicine, Veterans Administration Medical Center, and University of California, San Diego, CA 92115

This study was designed to determine effects of reducing intake of total fat and increasing carbohydrate (glucose) on plasma lipoproteins. Eleven men were investigated. They were given two diets for 1 month each. One diet contained 40% of calories as fat with 20% saturated fatty acids, 10% monounsaturates and 10% polyunsaturates. The other diet contained 30% fat with equal amounts of each type of fatty acid. The 10% of fat removed from the latter was replaced by glucose. Six patients had significant reductions of cholesterol in total plasma and low density lipoprotein (LDL) on the 30% fat; for the group as a whole; however, the decrease was not statistically significant. Total triglycerides increased modestly (15%) and high density lipoprotein (HDL)-cholesterol fell significantly (14%) on replacement of 40% fat with 30% fat. Seven patients also were given a 30% fat diet containing fatty acids in the same proportions as in the 40% fat diet. A similar response was noted as when fatty acids were given in equal ratios. This study indicates that response to reduction in fat content is inconsistent. The majority of patients were responders; others, however, were not.

KEY WORDS: • saturated fats • carbohydrate • plasma cholesterol • triglycerides • low density lipoproteins • high density lipoproteins • low fat diet

¹ Address reprint requests to Dr. Scott M. Grundy, Center for Human Nutrition, University of Texas Health Science Center, Dallas, Texas 75235.

Manuscript received 1 November 1982.