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Effects of Bone Fracture and Starvation-Refeeding on Lipogenesis in Rats¹

Department of Foods and Nutrition, University of Georgia, Athens, GA 30602

The effects of trauma and/or starvation-refeeding on lipogenesis in rats was studied. Male Sprague-Dawley rats were subjected to fracture of the right femur and either ad libitum fed or starved for 48 hours and refed a 65% glucose diet for 48 hours. Lipogenesis was assessed in terms of glucose-6-phosphate dehydrogenase activity or the incorporation of ³HOH into lipids by liver and adipose tissue. Traumatized rats differed little from control rats in their lipogenic activity, whereas starved-refed and starved-refed-traumatized rats had greatly increased lipogenic activities. These results suggest that the fatty liver that frequently develops as a consequence of trauma in humans may be due to their decreased food intake rather than to the trauma itself.

KEY WORDS: • trauma • starvation-refeeding • lipogenesis • fatty liver

¹ Data are from a thesis submitted by Paula J. Klose in partial fulfillment of the requirements for the M.S. degree. This work was supported by U.S. Department of Agriculture Human Nutrition Competitive Grant #5901-04100-0072-0.

² Present address: 938 Lilac Avenue, East Lansing. MI 48823.

³ To whom correspondence should be addressed.

Manuscript received 1 October 1982.