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Correlation between the Cholesterolemic Responses Produced by Dietary Cholesterol and Casein in Rabbits¹

Department of Human Nutrition, Agricultural University, De Dreijen 12, 6703 BC Wageningen ^* Department of Animal Genetics, Veterinary Faculty, State University of Utrecht, Yalelaan 17, 3584 CL Utrecht, The Netherlands

Rabbits were fed three semipurified diets, namely a cholesterol-free soy protein diet, a cholesterol-free casein diet or a diet containing soy protein plus cholesterol (2 g/kg). One group (Chol-Cas) of 24 rabbits was fed successively the diet containing soy protein plus cholesterol (25 days), the soy protein diet (36 days) and the casein diet (20 days). Another group (Cas-Chol) consisting of 25 animals received consecutively the diet containing casein, soy protein and soy protein supplemented with cholesterol. Hypercholesterolemia was induced by the diets containing cholesterol or casein, whereas regression was seen on the soy protein diet. Within the Chol-Cas or Cas-Chol group the cholesterolemic response to casein and that to cholesterol was significantly correlated, the correlation coefficient being as high as 0.66. This correlation was still observed when calculated for animals either hypo- or hyperresponsive to dietary casein or cholesterol. When all animals were pooled, the correlation coefficient for the cholesterolemic response to casein and to cholesterol was only 0.33. The mean response to dietary cholesterol and to casein was significantly higher in the last dietary period than in the first period.

KEY WORDS: • dietary casein • dietary cholesterol • serum cholesterol concentration • rabbit

¹ Part of this work was supported by the Netherlands Heart Foundation. grant no. 31.013.

² K.E.S. was supported by the Netherlands Nutrition Foundation and by an International Agriculture Centre fellowship from the Dutch Ministry of Agriculture and Fisheries.

³ To whom correspondence should be addressed.

Manuscript received 29 October 1982.