QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Quig, D. W. Articles by Hackler, L. R. Search for Related Content PubMed PubMed Citation Articles by Quig, D. W. Articles by Hackler, L. R.

The Influence of Starvation and Refeeding on the Lipoprotein Lipase Activity of Skeletal Muscle and Adipose Tissue of Lean and Obese Zucker Rats¹

David W. Quig^2,*, Donald K. Layman^*, Peter J. Bechtel and L. Ross Hackler^*

^* The Department of Foods and Nutrition Animal Science, University of Illinois, Urbana, IL 60801

Lipoprotein lipase (LPL) activities of skeletal muscles, heart and adipose tissue were investigated during feeding, prolonged food restriction, and refeeding. The influence of the duration of starvation on adipose tissue LPL activity was to cause it to decrease throughout starvation, whereas heart LPL activity increased during the first 24 hours of fasting and then declined for the remainder of the fast. Starvation of 10–24 female, lean and obese rats to 80% of initial body weight required 5 and 9 days, respectively. In fed controls, no differences between phenotypes were found for any tissue in the LPL activities expressed per gram tissue. However, obese rats exhibited significantly smaller muscle mass and a resulting 29% lower total skeletal muscle LPL activity. No phenotype differences were detected for tissue LPL activities during starvation or refeeding. During caloric restriction, the LPL activities were reduced in heart (-18%) and adipose (-52%) tissues, but skeletal muscle was unchanged except for the slow-twitch, oxidative soleus muscle, which was increased approximately two-fold. After refeeding to initial body weight, the LPL activity of heart returned to normal, but adipose tissue was dramatically increased (+300%) for both lean and obese Zucker rats. These data suggest that reduced skeletal muscle mass with normal LPL activity per gram tissue may contribute to an increased availability of plasma triglyceride fatty acids to adipose tissue of the genetically obese rat.

KEY WORDS: • lipoprotein lipase • skeletal muscle • starvation • Zucker rats

¹ Supported in part by National Institutes of Health Grant (HD 16401) and U.S. Department of Agriculture (ILLU 60-336).

² Supported in part by a Jessie E. Hackett Fellowship from the College of Agriculture, University of Illinois.

Manuscript received 22 October 1982.

This article has been cited by other articles:

				M. R. Jackman, A. Steig, J. A. Higgins, G. C. Johnson, B. K. Fleming-Elder, D. H. Bessesen, and P. S. MacLean Weight regain after sustained weight reduction is accompanied by suppressed oxidation of dietary fat and adipocyte hyperplasia Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1117 - R1129. [Abstract] [Full Text] [PDF]