QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Siewicki, T. C. Articles by Sydlowski, J. S. Search for Related Content PubMed PubMed Citation Articles by Siewicki, T. C. Articles by Sydlowski, J. S.

Iron Metabolism of Mice Fed Low Levels of Physiologically Bound Cadmium in Oyster or Cadmium Chloride¹

National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Southeast Fisheries Center, Charleston Laboratory, P.O. Box 12607, Charleston, SC 29412-0607

Three feeding studies were conducted with young mice to compare the toxicity of cadmium (Cd) occurring in oyster tissue to that of cadmium chloride (CdCl₂). In the first experiment, 5 or 20 ppm dietary Cd as CdCl₂ depressed blood hematocrit and hemoglobin concentrations, which were further depressed by the addition of up to 3% oyster to the diet. In the second experiment, 1.5 or 3.0 ppm dietary Cd as CdCl₂ did not influence hematopoiesis after 14 days exposure. The percent of the Cd dose retained in the kidney was inversely related to dosage level, directly related in the liver and femur and unaffected by dosage level in the small intestine. The liver-to-kidney ratio of retained Cd increased markedly with dose. In the last experiment, 0, 1.8 or 3.6 ppm Cd as CdCl₂ or 1.8 ppm Cd from oyster was fed to mice for 28 days. Diets containing intrinsic oyster Cd at 1.8 ppm were more effective than diets containing CdCl₂ at 3.6 ppm Cd for depressing total serum iron (Fe) and percent transferrin saturation and for enhancing ceruloplasmin activity. Oyster Cd was retained at a much lower rate in all tissues compared to CdCl₂. Oyster Cd was preferentially retained in the kidney compared to the liver. Intrinsic oyster Cd may be more potent in altering normal Fe metabolism than CdCl₂. Interactions with other dietary constituents in oysters which may also influence Fe metabolism, particularly zinc (Zn) and copper (Cu), are discussed.

KEY WORDS: • cadmium • iron • anemia • oysters • hematopoiesis

¹ Contribution number 83-12C, Southeast Fisheries Center, National Marine Fisheries Service, NOAA, Charleston, SC 29412.

Manuscript received 30 September 1982.