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Retinoids Induce Differentiation of Type A Spermatogonia In Vitro: Organ Culture of Mouse Cryptorchid Testes

Tatsuji Haneji1, Mamiko Maekawa and Yoshitake Nishimune

Department of Microbial Genetics, Research Institute for Microbial Diseases, Osaka University, Yamada-Oka, Suita City, Osaka 565, Japan

To study the effects of retinoids on testicular germ cell differentiation, especially on stem cells, artificially induced cryptorchid testes of adult mice were cultured in vitro inasmuch as they contain only stem cells, type A spermatogonia. We report here that retinol, retinal, retinol acetate, even retinoic acid, activated cell division in type A spermatogonia and stimulated them to differentiate. These findings are the first demonstration of the in vitro induction of early stage of spermatogenesis by retinoids and also retinoic acid, which is considered to be a biochemically inactive compound for mammalian testicular function.

KEY WORDS: • testis • spermatogenesis • vitamin A • organ culture

1 Present address: Department of Biochemistry, Fukuoka Dental College. Sawara-Ku, Fukuoka, 814-01 Japan

Manuscript received 4 October 1982.


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