QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chipalkatti, S. Articles by Aiyar, A. S. Search for Related Content PubMed PubMed Citation Articles by Chipalkatti, S. Articles by Aiyar, A. S.

Effect of Diet Restriction on Some Biochemical Parameters Related to Aging in Mice

Biochemistry & Food Technology Division, Bhabha Atomic Research Centre, Bombay 400085 India

The effects of chronic diet restriction in mice on some biochemical parameters related to aging have been investigated. Restriction of food intake to about one-half of the ad libitum consumption resulted in a significantly decreased growth rate immediately after weaning. In the experimental mice killed after different periods on a restricted diet up to 12 months, in vitro lipoperoxidation, the percent free activities of lysosomal enzymes and the accumulation of lipofuscins in tissues such as brain and heart were lower in comparison to those of the control animals. The superoxide dismutase activity in liver and brain did not show any consistent variations due to diet restrictions. These beneficial influences of decreased food intake on some free radical-mediated cellular damage may underlie its reported effects on longevity, in conformity with the free radical theory of aging.

KEY WORDS: • diet restriction • free radical • aging • lipofuscins • lipoperoxidation • lysosomal enzymes • superoxide dismutase

¹ Present address: Executive Director, Protein Foods and Nutrition, Development Association of India, Mahalaxmi Chambers, 22, Bhulabhai Desal Road, Bombay-400 026 India

Manuscript received 22 October 1982.

This article has been cited by other articles:

				A. J. Hulbert, R. Pamplona, R. Buffenstein, and W. A. Buttemer Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals Physiol Rev, October 1, 2007; 87(4): 1175 - 1213. [Abstract] [Full Text] [PDF]

				A. Wu, X. Sun, F. Wan, and Y. Liu Modulations by dietary restriction on antioxidant enzymes and lipid peroxidation in developing mice J Appl Physiol, March 1, 2003; 94(3): 947 - 952. [Abstract] [Full Text] [PDF]