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Journal of Nutrition Vol. 113 No. 5 May 1983, pp. 1039-1045
Copyright © 1983 by American Society for Nutrition
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Utilization of Intravenously Administered ß-Cellobiose and Maltose by Young Pigs1

Dean W. Andersen, Tahia T. Daabees, A. E. Applebaum, L. J. Filer, Jr. and Lewis D. Stegink2

The Departments of Pediatrics, Biochemistry, and Anatomy, The University of Iowa, Iowa City, IA 52242

Intravenous solutions of glucose oligosaccharides are potential sources of carbohydrate-derived energy for patients requiring intravenous feeding. Relatively little is known about utilization of glucose oligosaccharides linked by ß-glucosidic bonds. We compared the utilization of maltose ({alpha}-D-glucosyl-1,4-D-glucose) and ß-cellobiose (ß-D-glucosyl-1,4-D-glucose) when administered intravenously (19 g per day) to young pigs for a 5-day period. Animals infused with maltose excreted 15% of the infused disaccharide over the 5-day infusion period. No evidence of maltose accumulation was noted in plasma, and kidney morphology was normal. Animals infused with ß-cellobiose excreted 95% of the infused disaccharide in the urine. The mean (±SD) plasma total glucose concentration increased significantly over base-line values of 114 ± 39 mg/dl to a value of 180 ± 28 mg/dl during cellobiose infusion, indicating accumulation of cellobiose in body water. Kidney morphology in cellobiose-infused animals was normal. Intravenously infused ß-cellobiose is poorly utilized by the pig when compared with the utilization of its {alpha}-1,4 linked isomer, maltose.

KEY WORDS: • maltose • cellobiose • intravenous feeding • pig

1 Supported in part by a grant-in-aid from Abbott Laboratories, North Chicago, IL 60064.

2 To whom reprint requests should be sent: L.D.S., Department of Pediatrics, S385 Hospital School, The University of Iowa, Iowa City, IA 52242

Manuscript received 22 November 1982.




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