QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ruttenberg, H. Articles by Kritchevsky, D. Search for Related Content PubMed PubMed Citation Articles by Ruttenberg, H. Articles by Kritchevsky, D.

Influence of Trans Unsaturated Fats on Experimental Atherosclerosis in Rabbits^1,2,

The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, PA 19104

To test the effects of trans unsaturated fatty acids (t-FA) on atherosclerosis, lipidemia and enzyme activities, rabbits were fed a semipurified, cholesterol-free diet containing 40% sucrose, 25% casein and 14% fat for 5 months. Two experimental diets provided either 6% (high) or 3.2% (low) t-FA. The control group was fed a fat of composition similar to the two experimental diets but free of t-FA. Serum cholesterol and triglycerides were elevated in the rabbits fed 6% t-FA. Liver glycerides were also elevated in this group. The fatty acids of plasma, erythrocytes, epididymal fat, liver microsomes and liver mitochondria reflected the dietary composition. Levels of aortic atherosclerosis were identical in the three groups. There were no significant differences in activity of five hepatic enzymes: glucose-6-phosphatase (microsomal), fatty acid synthetase (cytosolic), malate dehydrogenase, ß-hydroxybutyrate dehydrogenase and monoamine oxidase (mitochondrial).

KEY WORDS: • aortic lipids • atherosclerosis • epididymal fat lipids • fatty acid synthetase • glucose-6-phosphatase • ß-hydroxybutyrate dehydrogenase • liver lipids • malate dehydrogenase • monoamine oxidase • serum lipids • trans unsaturated fatty acids

¹ This work was supported, in part, by grants HL-03299, HL-05209 and HL-23625 and a Research Career Award (HL-00734) from the National Institutes of Health.

² Presented, in part, at the Federation of American Societies for Experimental Biology Meeting, Anaheim, CA, 1980. Fed. Proc. 39: 1039, 1980.

³ To whom reprint requests should be sent: David Kritchevsky, The Wistar Institute, 36th Street at Spruce, Philadelphia, PA 19104.

Manuscript received 1 December 1982.

This article has been cited by other articles:

				B. Ames Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases Science, September 23, 1983; 221(4617): 1256 - 1264. [Abstract] [PDF]