Journal of Nutrition

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Journal of Nutrition Vol. 113 No. 4 April 1983, pp. 766-772
Copyright © 1983 by American Society for Nutrition
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Platelet Arachidonate Metabolism and Platelet Function in Zinc-Deficient Rats1

P. R. Gordon2, J. D. Browning and B. L. O'Dell3

Department of Biochemistry, University of Missouri, Columbia, MO 65211

To determine the effect of zinc status on arachidonate metabolism and the initiation of aggregation by a prostaglandin endoperoxide analog (U-44069), immature rats were fed for 5 days a low zinc (<1 ppm) or control (100 ppm Zn) diet based on soybean protein. In vitro production of thromboxane B2 (TXB2) by plateletrich plasma after stimulation by either arachidonate (0.2 mM) or ADP (0.2 µM) was not changed by dietary zinc deprivation, even though bleeding time was prolonged. Oxygenation of exogenous arachidonate, catalyzed by either the cyclooxygenase or lipoxygenase pathway, was not affected by zinc deficiency. Platelet aggregation in response to the prostaglandin endoperoxide analog at both 8 and 16 µM was impaired by dietary zinc deprivation. While short-term zinc deprivation decreased platelet response to minimal levels of agregating agents, production of arachidonate metabolites was unimpaired. It is postulated that platelet response to the products of arachidonate metabolism is reduced.

KEY WORDS: • zinc deficiency • bleeding time • platelet aggregation • thromboxane • prostaglandin endoperoxide • arachidonate

1 Contribution of the Missouri Agricultural Experiment Station, Journal Series No. 9172. Supported in part by Public Health Service Grant HL11614.

2 Present address: Harvard Medical School, Boston, MA.

3 To whom correspondence should be addressed.

Manuscript received 26 July 1982.




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