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Glycerol Kinase Activity in Adipose Tissue of Obese Rats and Mice: Effects of Diet Composition¹

Department of Human Behavior and Metabolism, The Rockefeller University, New York, NY 10021, and ^* Department of Biochemical Nutrition, Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110

Glycerol kinase activity was measured in isolated fat cells from Zucker obese (fa/fa) rats, obese (ob/ob) mice, mice made obese by gold-thioglucose (GTG), yellow obese (Ay/a) mice, as well as their appropriate lean controls. Glycerol kinase activity per fat cell was elevated in all obese rodents relative to lean controls, and was generally correlated with adipose cell size. Enzyme activity was higher following high fat than following high carbohydrate feeding.

KEY WORDS: • obesity • glycerokinase • diet

¹ Supported in part by National Institutes of Health Grant AM18899 and a grant from the Weight Watchers Foundation.

² Please address reprint requests to Dr. Judith S. Stern. Department of Nutrition, University of California, Davis, CA 95616.

Manuscript received 3 September 1982.