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Journal of Nutrition Vol. 113 No. 3 March 1983, pp. 704-713
Copyright © 1983 by American Society for Nutrition
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Dietary Trilinoelaidate: Effects on Hematological Parameters, Serum Eicosanoids and Tissue Fatty Acid Composition in Rats1

Geza Bruckner, Susan Trimbo, Satindra Goswami and John E. Kinsella

Department of Food Science, Cornell University, Institute Food Science, Ithaca, NY 14853

Increasing levels of tt18:2 were fed to rats for 11 weeks and the following parameters evaluated: bleeding time; platelet and red blood cell (RBC) counts; packed RBC volume; RBC hemolysis; (none of which were affected) and RBC calcium content; myeloid/erythroid marrow ratios (M/E); fatty acid composition of plasma and heart lipids, and serum eicosanoids, e.g., thromboxane B2 (TXB2) and 6-ketoprostaglandin F1{alpha} (6-keto). At the highest level of tt18:2 fed (6.3 en%), there was a notable decrease in RBC calcium content. Furthermore, this level of tt18:2 (6.3 en%) significantly decreased M/E ratios compared to normal, as did lower tt18:2 levels. Plasma and heart fatty acids reflected expected changes with increasing dietary tt18:2. Serum TXB2 versus 6-keto levels were more indicative of dietary trilinoelaidate intervention. TXB2 levels were significantly decreased with no apparent change in 6-keto serum levels in the rats fed 6.3 en% tt18:2 compared to control. Although the consumption of trilinoelaidate, at levels approximating normal human intake, (0.6 en%) is apparently not deleterious to any of the hematologic criteria studied; higher levels precipitate changes in M/E ratios, RBC calcium content and serum TXB2 levels. Therefore, until more physiological parameters have been evaluated, dietary tt18:2 seems to be without detrimental effects.

KEY WORDS: • trilinoelaidate • hematology • trans fatty acids • thromboxane

1 Supported by U.S. Department of Agriculture Grant No. 5901-0410-9-0286-0.

Manuscript received 27 October 1982.




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