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Teratogenic Effects of Biotin Deficiency in Mice¹

Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Zao-Iida, Yamagata City, 990-23, Japan

Teratogenic effects of maternal biotin deficiency produced by a diet containing egg white were studied in mice. More than 90% of the fetuses from biotin-deficient females showed external or skeletal congenital abnormalities. The predominant malformations were micrognathia (91%), cleft palate (82%) and micromelia (41%). Simultaneous supplementation of biotin at the level of 10 mg/kg in the diet thoroughly prevented these malformations. Thus congenital malformations observed in this study were apparently due to the maternal dietary deficiency of biotin during pregnancy. Even though so many fetuses were malformed and many were also stunted, their dams did not exhibit any overt signs of biotin deficiency such as alopecia, dermatitis or nervous irritability.

KEY WORDS: • biotin deficiency • teratogenic effect • pregnancy • egg white • mouse

¹ This work was presented in part at the 22nd Annual Meeting of the Japanese Teratology Society, Tokyo, July 8–9, 1982, Japan.

Manuscript received 11 August 1982.

This article has been cited by other articles:

				R. Takechi, A. Taniguchi, S. Ebara, T. Fukui, and T. Watanabe Biotin Deficiency Affects the Proliferation of Human Embryonic Palatal Mesenchymal Cells in Culture J. Nutr., April 1, 2008; 138(4): 680 - 684. [Abstract] [Full Text] [PDF]