QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Finkelstein, J. D. Articles by Kyle, W. E. Search for Related Content PubMed PubMed Citation Articles by Finkelstein, J. D. Articles by Kyle, W. E.

Regulation of Hepatic Betaine-Homocysteine Methyltransferase by Dietary Betaine¹

Veterans Administration Medical Center and George Washington University School of Medicine, Washington, D. C. 20422

The level of betaine-homocysteine methyltransferase increases in the livers of rats fed diets supplemented with betaine or choline. The increase occurs within 3 days following the change in diet. When we administered betaine by intraperitoneal injection to rats fed choline-free diets, we observed a similar increase within 24 hours. Since betaine-homocysteine methyltransferase catalyzes a reaction which is essential for the catabolism of betaine, these changes provide a means for adaptation to excessive levels of dietary choline and betaine.

KEY WORDS: • betaine-homocysteine methyltransferase • betaine • choline

¹ These studies were supported by the Veterans Administration and by National Institutes of Health Grant AM-13048.

Manuscript received 29 July 1982.

This article has been cited by other articles:

				J. M. Davison, T. J. Mellott, V. P. Kovacheva, and J. K. Blusztajn Gestational Choline Supply Regulates Methylation of Histone H3, Expression of Histone Methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA Methylation of Their Genes in Rat Fetal Liver and Brain J. Biol. Chem., January 23, 2009; 284(4): 1982 - 1989. [Abstract] [Full Text] [PDF]

				K. A. Clow, J. R. Treberg, M. E. Brosnan, and J. T. Brosnan Elevated Tissue Betaine Contents in Developing Rats Are Due to Dietary Betaine, Not to Synthesis J. Nutr., September 1, 2008; 138(9): 1641 - 1646. [Abstract] [Full Text] [PDF]

				V. P. Kovacheva, T. J. Mellott, J. M. Davison, N. Wagner, I. Lopez-Coviella, A. C. Schnitzler, and J. K. Blusztajn Gestational Choline Deficiency Causes Global and Igf2 Gene DNA Hypermethylation by Up-regulation of Dnmt1 Expression J. Biol. Chem., October 26, 2007; 282(43): 31777 - 31788. [Abstract] [Full Text] [PDF]

				R. N. Dilger, T. A. Garrow, and D. H. Baker Betaine Can Partially Spare Choline in Chicks but Only When Added to Diets Containing a Minimal Level of Choline J. Nutr., October 1, 2007; 137(10): 2224 - 2228. [Abstract] [Full Text] [PDF]

				C. A. Loest, E. C. Titgemeyer, G. S.-J. D. C. Van Metre, and J. S. Smith Methionine as a methyl group donor in growing cattle J Anim Sci, August 1, 2002; 80(8): 2197 - 2206. [Abstract] [Full Text] [PDF]