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Journal of Nutrition Vol. 113 No. 3 March 1983, pp. 519-521
Copyright © 1983 by American Society for Nutrition
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Regulation of Hepatic Betaine-Homocysteine Methyltransferase by Dietary Betaine1

James D. Finkelstein, John J. Martin, Barbara J. Harris and Walter E. Kyle

Veterans Administration Medical Center and George Washington University School of Medicine, Washington, D. C. 20422

The level of betaine-homocysteine methyltransferase increases in the livers of rats fed diets supplemented with betaine or choline. The increase occurs within 3 days following the change in diet. When we administered betaine by intraperitoneal injection to rats fed choline-free diets, we observed a similar increase within 24 hours. Since betaine-homocysteine methyltransferase catalyzes a reaction which is essential for the catabolism of betaine, these changes provide a means for adaptation to excessive levels of dietary choline and betaine.


KEY WORDS: • betaine-homocysteine methyltransferase • betaine • choline

1 These studies were supported by the Veterans Administration and by National Institutes of Health Grant AM-13048.

Manuscript received 29 July 1982.


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