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The Effect of Dietary Manganese Deficiency on Cholesterol and Lipid Metabolism in the Wistar Rat and in the Genetically Hypercholesterolemic RICO Rat¹

D. J. Klimis-Tavantzis^2,*, R. M. Leach, Jr.^3, and P. M. Kris-Etherton

The^* Nutrition Program, College of Human Development Department of Poultry Science, College of Agriculture, The Pennsylvania State University, University Park, PA 16802

Two experiments were conducted to determine the effect of dietary manganese on cholesterol and lipid metabolism in the Wistar rat and the genetically hypercholesterolemic RICO rat. Weanling animals were placed on a manganese-deficient (0.12 µg/g) and a supplemented diet (100.12 µg/g). Mean body weights, hepatic fatty acid synthesis and liver manganese concentration significantly decreased in the deficient group of Wistar rats. Plasma cholesterol, VLDL (very low density lipoprotein) and HDL (high-density lipoprotein) cholesterol, hepatic cholesterol synthesis, liver cholesterol and lipid concentrations were not significantly affected by manganese deficiency. Mean body weights and hepatic manganese content were lower in the manganese-deficient group in both normal and hypercholesterolemic RICO rats. Manganese deficiency significantly decreased LDL cholesterol concentration in the hypercholesterolemic RICO rats. Manganese deficiency had no significant effect on hepatic cholesterol and fatty acid synthesis, plasma cholesterol, VLDL and HDL cholesterol concentrations, liver lipid and liver cholesterol concentration in either group of RICO rats. These results indicate that dietary manganese deficiency does not result in significant alterations in cholesterol and lipid metabolism in the rat.

KEY WORDS: • manganese deficiency • cholesterol metabolism • lipid metabolism • RICO rat

¹ Authorized for publication on July 8, 1982 as Paper No. 6477 in the Journal Series of the Pennsylvania Agricultural Experiment Station.

² Current address: 3 Webster Road, Orono, Maine 04473. Submitted in partial fulfillment of a Ph.D. degree in Nutrition.

³ Address correspondence to: R. M. Leach, Jr., Department of Poultry Science, 205 Animal Industries Building, Pean State University, University Park, PA 16802.

Manuscript received 19 July 1982.