Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 113 No. 2 February 1983, pp. 253-267
Copyright © 1983 by American Society for Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, S. A.
Right arrow Articles by Zeman, F. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, S. A.
Right arrow Articles by Zeman, F. J.

Maternal and Embryonic Response to a "Carbohydrate-Free" Diet Fed to Rats1

Sharon A. Taylor, Ruth E. Shrader, Kristine G. Koski and Frances J. Zeman

Department of Nutrition, University of California, Davis, CA 95616

The effects of a carbohydrate-free, fatty acid (CF) diet on pregnant rats and their progeny were examined. A pregnant pair-fed group was included to compensate for the 40% reduction in food intake of the CF dams. Control and CF dams were killed on days 6, 8, 10, 12, or 14 of gestation. Pair-fed dams were killed on day 14. Maternal CF rats were hypoglycemic and hyperketonemic as compared to pair-fed or control dams. Both CF and pair-fed dams had significantly reduced liver glycogen. Diet had no effect on the number of implantation sites. Conceptuses were classified histologically as normal, retarded, malformed, degenerating or resorbed. Numbers of normal CF embryos were significantly reduced from day 6 and, by day 12, all CF embryos had been resorbed. Control and pair-fed dams showed 5.2% and 43.8% resorptions, respectively, on day 14. These data suggest that approximately half of the embryonic loss can be attributed to the reduction in food intake whereas the remaining embryos succumbed to embryolethal conditions more directly related to the metabolic consequences of carbohydrate deprivation.

KEY WORDS: • carbohydrate • embryonic • development • rat

1 Presented in part at the annual meeting of the Federation of American Societies for Experimental Biology, New Orleans, 1982, Fed. Proc. 41: 358 (abs.).

Manuscript received 14 June 1982.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]