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The Effect of Wheat Bran on the Bioavailability of Vitamin B-6 in Young Men^{1, 2,}

Department of Foods and Nutrition, Oregon State University, Corvallis, OR 97331

The effect of cooked wheat bran on the bioavailability of vitamin B-6 (B-6) was determined in 10 men, aged 20 to 35 years. The subjects consumed a constant diet with and without the addition of 15 g wheat bran during three successive 18-day periods in a switch-back design. Half of the subjects received the additional bran during periods 1 and 3; the other half consumed the bran during period 2. The bran and nonbran diets supplied, respectively, 1.69 and 1.66 mg of B-6 daily. Plasma total B-6 and pyridoxal phosphate (PLP), urinary 4-pyridoxic acid (4-PA), and urinary and fecal B-6 were determined at regular intervals during each period. Bran significantly increased fecal B-6 (P < 0.05) and decreased urinary 4-PA (P < 0.01). Bran also significantly depressed plasma B-6 (P < 0.01) and PLP (P < 0.05). These results indicate that the addition of 15 g of wheat bran to the diet decreased the bioavailability of B-6. Since this decrease was modest, never exceeding 17% (based on urinary 4PA and B-6), this amount of bran will not adversely affect B-6 status when intake of the vitamin is adequate.

KEY WORDS: • wheat bran • vitamin B-6 • bioavailability • pyridoxal phosphate • 4-pyridoxic acid

¹ Oregon Agricultural Experiment Station Paper No. 6844.

² Supported in part by U.S. Department of Agriculture Competitive Research Grant 616-15-177. A preliminary report was presented at the meeting of Federation of American Societies for Experimental Biology in Dallas, TX, April 1-10, 1979; Miller, L. T., Lindberg, A. S., Whanger, P. D. & Leklem, J. E. (1979) Effect of wheat bran on the bioavailability of vitamin B-6 and the excretion of selenlum in man. Fed. Proc. 38:767.

³ Present address: International Community Health Center, 416 May-nard Ave, S., Seattle, WA 98104.

⁴ To whom requests for reprints should be addressed. (503/754-3281).

Manuscript received 31 May 1983.