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Journal of Nutrition Vol. 113 No. 11 November 1983, pp. 2300-2307
Copyright © 1983 by American Society for Nutrition
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Effects of Bran, Lignin and Deoxycholic Acid on the Permeability of the Rat Cecum and Colon1

Craig P. Gyory2 and George W. Chang3

Department of Nutritional Sciences, University of California, Berkeley, CA 94720

The ability of dietary fiber to modify the effects of a bile acid on permeability of the cecum and colon was studied. A cecal catheter, which permits administration of test materials to conscious, unrestrained rats over a period of several weeks, was designed. Rats were fed fiber-free diet or diets containing 20% bran or lignin. Permeability of the lower intestine was assessed indirectly by infusing polyethylene glycol (PEG) and measuring excretion of PEG in urine. Under these conditions there was little effect of diet on permeability of PEG. However, when sodium deoxycholate was infused with the PEG, permeability was increased in rats fed fiber-free and diets. In contrast, rats fed the bran diet showed no such response to the bile acid. The interaction among type of dietary fiber, presence of bile acid and intestinal permeability may have important implications for the etiology of intestinal disease.

KEY WORDS: • dietary fiber • intestinal permeability • bile acid • bran • lignin

1 Supported by National Institutes of Health Grant #AM 19970 and National Science Foundation Grant PFR-79-19105 from the Human Nutrition Program of the National Science Foundation.

2 Present address: Johns Hopkins University Medical School, Baltimore, MD 21205.

3 To whom reprint requests should be sent.

Manuscript received 10 January 1983.




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