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Journal of Nutrition Vol. 113 No. 11 November 1983, pp. 2295-2299
Copyright © 1983 by American Society for Nutrition
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The Influence of Cysteine and Methionine Supplements on Polyamine Biosynthesis in the Rat

Robert V. Acuff and John T. Smith

Department of Surgery, East Tennessee State University, Johnson City, TN 37614-0002 and the Department of Nutrition and Food Sciences The University of Tennessee, 1, Knoxville, TN 37996-1900

Previous reports from this laboratory have shown that supplementation of diets containing the optimal level (0.02%) of dietary inorganic sulfate (SO42-) with cysteine instead of methionine can affect several metabolic pathways. It is possible that these results reflect alterations in the biosynthesis of potent physiological compounds, the polyamines. Adult male albino rats were fed diets containing 15% casein and a constant level of inorganic sulfate (0.02%) supplemented with cysteine (0.505%) or methionine (0.62%). The polyamines (putrescine, spermidine and spermine) and the controlling enzymes for their biosynthesis ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMD) were evaluated in liver, kidney and brain tissue homogenates following a 17-day dietary period. Rats fed the diet supplemented with cysteine had increased ODC activity and decreased SAMD activity when compared to rats fed diets supplemented with methionine. Polyamine concentrations varied in tissues with a trend toward increasing amounts in animals fed the cysteine-supplemented diet. Based on these data, it appears that dietary cysteine stimulates the biosynthesis and increased tissue concentration of polyamines.

KEY WORDS: • cysteine • methionine polyamines

1 Published with permission of the Dean of the Agricultural Experiment Station and the Dean of the College of Home Economics.

Manuscript received 31 May 1983.




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