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Journal of Nutrition Vol. 113 No. 11 November 1983, pp. 2138-2146
Copyright © 1983 by American Society for Nutrition
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Distribution of Selenium and Glutathione Peroxidase in Blood Fractions from Humans, Rhesus and Squirrel Monkeys, Rats and Sheep1,2,3,

M. A. Beilstein and P. D. Whanger

Department of Agricultural Chemistry, Oregon State University, Corvallis, OR 97331

The distribution of selenium and glutathione peroxidase (GSH-Px) was investigated in blood fractions from humans, rhesus and squirrel monkeys, sheep and rats by gel filtration (Sephadex G-150). The majority of selenium in plasma and erythrocytes from sheep, squirrel monkeys and rats cochromatographed with GSH-Px. In contrast, selenium in plasma from humans and rhesus monkeys cochromatographed with two non-GSH-Px proteins and nearly all of the selenium in erythrocytes cochromatographed with the hemoglobin peak. A significant amount of GSH-Px activity in rhesus monkey and human erythrocytes also cochromatographed with the hemoglobin fraction, but very little GSH-Px coeluted with hemoglobin from squirrel monkeys, ovine and rat blood. The results suggest that GSH-Px activity may not be a good measure of selenium status in higher primates.

KEY WORDS: • humans • glutathione peroxidase • selenium • gel filtration • blood • monkeys • rats • sheep

1 Published with the approval of the Oregon State Agricultural Experiment Station as Technical Paper No. 6759.

2 Supported by U.S. Department of Agriculture Grant Number 8000566 from the Competitive Research Grants Program and by Public Health Service Research Grant Number AM 21037 from the National Institute of Arthritis, Metabolism and Digestive Diseases.

3 Beilstein, M. A., Whanger, P.D. & Schimerlik, M. (1983) Selenium and giutathione peroxidase distribution in blood fractions from bumans, rhesus monkeys, sheep and rats. Fed. Proc. 42, 926.

Manuscript received 8 April 1983.




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