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Effect of Dietary Level of Vitamin E on the Immune System of the Spontaneously Hypertensive (SHR) and Normotensive Wistar Kyoto (WKY) Rat

Vitamins and Clinical Nutrition Section, Hoffmann-LaRoche Inc., Nutley, NJ 07110

Spontaneously hypertensive rats (SHR) had depressed splenic mitogen responses as well as lower splenic vitamin E when compared to normotensive Wistar Kyoto strain (WKY) rats fed a stock diet. Both strains had depressed T- and B-cell splenic mitogen responses after 17 weeks on a semipurified, vitamin E-deficient diet when compared to animals fed either stock or dl--tocopheryl acetate-supplemented semipurified diet. In addition, SHR fed the vitamin E-supplemented diet had enhanced thymocyte rosetting compared to those fed the vitamin E-deficient diet. In contrast, the dietary vitamin E level did not affect the thymocyte rosetting in WKY rats.

KEY WORDS: • vitamin E • spontaneously hypertensive rat • immune responses • spleen mitogen • thymocyte rosetting

Manuscript received 23 March 1983.