QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Struthers, B. J. Articles by Hopkins, D. T. Search for Related Content PubMed PubMed Citation Articles by Struthers, B. J. Articles by Hopkins, D. T.

Effects on the Monkey, Pig and Rat Pancreas of Soy Products with Varying Levels of Trypsin Inhibitor and Comparison with the Administration of Cholecystokinin¹

Ralston Purina Company, St. Louis, MO 63164

Raw and heated soy flour and casein diets were compared in rats, pigs, and monkeys with respect to growth, pancreatic changes, fecal trypsin, and nitrogen digestibility. Cholecystokinin injection was compared to feeding raw soy flour and casein in rats and casein in pigs. Several soy protein preparations were fed to rats and monkeys. Neither raw soy flour nor any other soy product produced pancreatic enlargement in pigs or monkeys. Casein and heated soy flour performed similarly. By comparison, other effects of raw soy flour were as follows. Growth was depressed 60% in rats and 84% in pigs, but not at all in monkeys. Nitrogen digestibility was depressed 5, 45, and 9% in rats, pigs, and monkeys, respectively. Pancreatic DNA, RNA, and protein levels were unchanged in monkeys fed raw soy flour. In rats, RNA per milligram pancreas was increased 40%, in pigs 20%. Pancreatic protein was decreased 7% in pigs and increased 47% in rats. Changes in pancreatic trypsin, chymotrypsin, lipase, and amylase were dissimilar in the three species. Fecal trypsin was elevated 300–400% in rats, and decreased approximately 50% in pigs and monkeys. Cholecystokinin injections in pigs and rats produced changes both quantitatively and qualitatively different from those seen with raw soy flour. Feeding of heated soy flour or soy protein isolates was comparable to feeding casein in all three species, and produced no deleterious effects.

KEY WORDS: • pancreas • pancreatic composition • enzymes • cholecystokinin • raw soy flour • soy proteins • fecal trypsin • rats • pigs • monkeys • trypsin inhibitor

¹ Presented in part at the 64th annual meeting of the Federation of American Societies for Experimental Biology, Anaheim, CA, April, 1980. Fed. Proc. 39: 377, 1980 (abs.). A portion of these data was presented in the Natl. Pancreatic Cancer Proj. Newsletter VI(2): 57, 1981 (abs.).

Manuscript received 3 June 1982.

This article has been cited by other articles:

				M. Tashiro, L. C. Samuelson, R. A. Liddle, and J. A. Williams Calcineurin mediates pancreatic growth in protease inhibitor-treated mice Am J Physiol Gastrointest Liver Physiol, May 1, 2004; 286(5): G784 - G790. [Abstract] [Full Text] [PDF]