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Excessive Intake of 13-cis Retinoic Acid and Fatty Acid Composition of Tissues^{1 ,2}

Department of Biochemistry, Louisiana State University Medical Center, 1100 Florida Avenue, New Orleans, LA 70119

The effects of feeding an excess of 13-cis retinoic acid on the fatty acid composition of tissues were studied. Groups of male, weanling, Sprague-Dawley rats were fed diets containing 0, 100 and 300 mg 13-cis retinoic acid per kilogram diet. Rats were killed 4 weeks after feeding the diets, and the fatty acid composition of total lipids in plasma, liver, kidney, heart and lung was determined. Changes in fatty acid patterns were observed primarily in plasma and liver. The proportions of 16:1, 18:1 and 20:36 were generally higher, whereas those of 20:4 were lower. The fatty acid composition of kidney, heart and lung lipids was not appreciably changed. The results on fatty acid changes in liver suggest that 13-cis retinoic acid may be modifying the activities of desaturating enzymes.

KEY WORDS: • 13-cis retinoic acid • fatty acid composition

¹ This study was supported by grant from Dr. C. B. Pennington.

² Presented in part at the annual meeting of the Federation of American Societies for Experimental Biology, New Orleans, LA, April 1982. Alam, S. Q. and Alam, B. S. (1982) Acyl group composition of tissues of rats fed 13-cis retinoic acid. Fed. Proc. 41, 357 (abs.)

Manuscript received 24 March 1982.

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