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The Biological Activity of Retinotaurine1

K. L. Skare2, W. K. Sietsema and H. F. DeLuca3

Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI 53706

The ability of the biliary metabolite retinotaurine to reverse the cornification of vaginal epithelial cells induced by vitamin A deficiency was assessed using a vaginal smear assay. Retinotaurine activity was examined following the intravaginal administration of 10-12 mol to 10-8 mol of this compound per vagina. This metabolite exhibited no detectable activity at any dose tested. These results show that retinotaurine cannot be more than 1% as active as all-trans-retinoic acid since retinoic acid shows a response at concentrations of 10-10 mol per vagina. The low biological activity of this recently identified biliary metabolite suggests that it represents an excretory form of retinoic acid.

KEY WORDS: • vitamin A • retinoids • epithelial differentiation • retinotaurine

1 This work was supported by a Program Project Grant No. AM-14881 from the National Institutes of Health, a Cellular and Molecular Biology Training Grant No. GM-07215, (W.K.S.), a predoctoral fellowship from Procter and Gamble (K.L.S.) and by the Harry Steenbock Research Fund of the Wisconsin Alumni Research Foundation.

2 Current address: Procter and Gamble, Research and Development Department, Miami Valley Laboratories, P.O. Box 39175, Cincinnati, OH 45247.

3 Author to whom correspondence should be addressed; no reprints available from authors.

Manuscript received 17 March 1982.




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Copyright © 1982 by American Society for Nutrition