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Changes in Mg⁺²-ATPase and Taurine Levels in Mg⁺²-Deficient Rats¹

Division of Animal and Veterinary Science, College of Agriculture and Forestry, West Virginia University, Morgantown, WV 26506

Tissue levels of Mg⁺²-ATPase and taurine were measured in rats fed Mg⁺²-deficient diets. Serum and urinary Mg⁺² levels of rats fed the deficient diet were 50% below the control levels by day 10 on diet. The Mg⁺²-deficient rats showed a significant decrease in intestinal Mg⁺²-ATPase relative to the controls, despite having no significant decrease in intestinal Mg⁺² levels. The effect of the Mg⁺² deficiency on the distribution of subcutaneously injected 1,2-[¹⁴C]taurine in the skeletal muscle cytosol and organelles was measured. The cytosolic fraction contained 90% of the [¹⁴C]taurine, while the nuclear fraction contained 98% of the noncytosolic [¹⁴C]taurine. The skeletal muscle of Mg⁺²-deficient rats contained 14, 14, 81 and 53% more [¹⁴C]taurine than the control muscle at 1, 16, 24 and 48 hours after injection, respectively. There was 21, 60, 97 and 350% more [¹⁴C]taurine associated with the nuclear fraction of the muscle from Mg⁺²-deficient rats at the same sampling periods.

KEY WORDS: • taurine • Mg⁺²-ATPase • magnesium • magnesium deficiency • small intestine • skeletal muscle

¹ Published with approval of director of the West Virginia Agricultural and Forestry Experiment Station as Scientific Paper No. 1752.

Manuscript received 11 March 1982.