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Journal of Nutrition Vol. 112 No. 7 July 1982, pp. 1414-1424
Copyright © 1982 by American Society for Nutrition
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A Mass Spectrometric Method for Use of Stable Isotopes as Tracers in Studies of Iron, Zinc, and Copper Absorption in Human Subjects

Phyllis E. Johnson

United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202

Stable isotopes of iron, zinc, and copper can be used singly and in combination as tracers of mineral metabolism in human subjects. A mass spectrometric method of analysis that uses chelation of these metals with tetraphenylporphyrin was developed. Absorption can be determined by measuring isotope appearance in feces after a single pulse dose. The method is satisfactory for 54Fe, 67Zn, and 65Cu. Detection of 57Fe and 70Zn in feces is not very reliable.

KEY WORDS: • stable isotopes • iron • zinc • copper • metal absorption • mass spectrometry

Manuscript received 20 January 1982.




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